Dual RAAS blockade in canine heart failure

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Question n°1

In which of the following locations can aldosterone receptors be found?

  • Aldosterone receptors are found on the heart - but are also present in other locations

  • Aldosterone receptors are found on the heart - but are also present in other locations

  • Aldosterone receptors are found on the heart - but are also present in other locations

  • CORRECT - aldosterone receptors are present in the heart, blood vessels and kidney, and their activation contributes to the worsening of heart failure.

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Question n°2

Which of the following is NOT associated with aldosterone?

  • Incorrect - in heart failure aldosterone does cause myocardial remodelling/ fibrosis, reducing the ability of the heart to contact properly.

  • Incorrect - in heart failure aldosterone does cause remodelling/ narrowing of the blood vessels, making it harder to pump blood around the body.

  • CORRECT - this statement is wrong. Aldosterone actually causes sodium and fluid retention

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Question n°3

Which of the following drugs has been shown to activate RAAS and increase aldosterone production?

  • CORRECT - furosemide has been shown to cause a 2-3 fold increase in aldosterone production, even in cases receiving an ACE Inhibitor.

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Question n°4

Bimodal suppression of the RAAS system refers to the combination of which two drugs?

  • CORRECT - this can now also be achieved by using Cardalis, which contains the ACE Inhibitor benazepril and spironolactone in one tablet.

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Question n°5

Which of the following statements regarding bimodal RAAS suppression is INCORRECT?

  • CORRECT - this statement is wrong. The benefits of bimodal suppression have been shown to occur when used as part of first-line heart failure therapy.

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